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Angiogenesis by HUVECs cultured in Type I collagen-fibrin mixed hydrogels. Variation of (A) elastic modulus and (B) average tube length and tube number (collagen:fibrin weight ratio: CF1 1:4; CF2 2:3; CF3 3:2; CF4 4:1). SEM and optical images (as insets) for (C) CF2 and (D) CF3. ** p < 0.01, * p < 0.05. Yellow arrows indicate banded collagen fibrils. Red asterisks indicate bundles of fibrils. Adapted and reproduced with permission from [132]. Copyright 2018 Elsevier B.V.
