Table 6.
Identified Variants Associated with Drug Resistance in the Genomes of the 19 Clinical Mycobacterium tuberculosis Complex Isolates.
| Sub lineage | Rif | INH | PZA | ETB | STM | FQ | AM | ETO | PAS | CS |
|---|---|---|---|---|---|---|---|---|---|---|
| 2_2_1_M_ Asian_ African_2 |
rpoB_p.Ser450Leu | katG_p.Ser315Thr | pncA_p.Gly97Asp | embB_p.Met306Val | rpsL_p.Lys43Arg | - | - | - | - | - |
| 2_2_2 | rpoB_p.His445Asp | katG_p.Ser315Thr | - | embB_p.Met306Ile | rpsL_p.Lys43Arg | - | - | - | - | - |
| 1_1_2_2 | - | katG_p.Ser315Thr | - | embB_p.Asp328Gly | rrs_r.514a > c | - | - | - | - | - |
| 2_2_1_Modern | - | katG_p.Ser315Thr | - | - | rrs_r.517c > t | - | - | - | - | - |
| 1_2_1 | - | katG_p.Ser315Thr | - | - | - | - | - | fabG1_c.-15C > T | - | - |
| 2_2_1_M_ Asian_ African_2 |
- | fabG1_c.-15C > T | - | - | - | - | - | fabG1_c.-15C > T | - | - |
| 1_1_3_1 | - | fabG1_c.-15C > T | - | - | - | - | - | fabG1_c.-15C > T | - | - |
| 2_2_1_Modern | - | katG_p.Ser315Thr | - | - | rpsL_p.Lys43Arg | - | - | - | - | - |
| 1_1_2_2 | - | - | panD_p.Ile49Val | - | - | - | - | ethA_c.1054_1054del | - | - |
| 2_2_1_Modern | - | - | - | - | rpsL_p.Lys43Arg | - | - | ethR_p.Ala95Thr | - | - |
| 1_1_1_8 | - | katG_p.Ser315Thr | - | - | - | - | - | - | - | - |
| 1_1_3 | - | katG_p.Ser315Thr | - | - | - | - | - | - | - | - |
| 1_1_3_1 | - | katG_p.Ser315Thr | - | - | - | - | - | - | - | - |
| 1_2_1_2 | - | katG_p.Ser315Thr | - | - | - | - | - | - | - | - |
| 1_2_2 | - | - | - | - | - | - | - | ethA_c.341_341del | - | - |
| 1_1_1 | - | ahpC_c.-52C > T | - | - | - | - | - | - | - | - |
| 2_2_1_Asia_ Ancestral_3 |
- | - | - | - | - | - | - | - | folC_p.Thr20Pro | - |
| 2_2_1_M_ Asian_ African_2 |
- | - | - | - | - | - | - | ethA_c.24_25insC | - | - |
| 1_2_2 | - | - | - | embB_p.Phe285Leu | - | - | - | - | - | - |
Rif: rifampicin; INH: isoniazid; PZA: pyrazinamide; ETB: ethambutol; STM: streptomycin; FQ: fluoroquinolones; AM: aminoglycosides; ETO: ethionamide; PAS: para-aminosalicylic acid; CS: cycloserine.