. 2020 Nov 13;45(1):13–28. doi: 10.3892/or.2020.7851

Table II.

Physicochemical properties of approved ALK-TKIs.

Properties	Crizotinib	Ceritinib	Brigatinib	Alectinib	Lorlatinib	Entrectinib
Molecular formula (mg/mole)	450.34	558.14	584.10	482.62	406.41	560.64
Molecular weight	C₂₁H₂₂Cl₂FN₅O	C₂₈H₃₆ClN₅O₃S	C₂₉H₃₉ClN₇O₂P	C₃₀H₃₄N₄O₂	C₂₁H₁₉FN₆O₂	C₃₁H₃₄F₂N₆O₂
Octanol/water	1.65 (pH 7.4)	5.23	5.17	NA	2.45 (pH 9)	NA
Water solubility	0.00611 mg/ml	0.00222 mg/ml	0.022 mg/ml	NA	32.38–0.17 (pH 2.55–8.02)	NA
pKa	9.4 and 5.6	9.7 and 4.1	NA	7.05 (base)	4.9	NA

ALK-TKIs, anaplastic lymphoma kinase tyrosine kinase inhibitors; NA, not available; pKa, symbol for acid dissociation constant at logarithmic scale.