Figure 2.

Therapeutic approaches for use of ncRNAs for targeting ferroptosis in cancer. In anticancer approaches, induction of the occurrence of ferroptosis by lipid ROS is the primary approach of ferroptosis based cancer therapy. Targeting ncRNA-related ferroptosis via activation of lipid and iron metabolism or suppression of antioxidant metabolism by ncRNA-guided nanoparticles, ncRNA modification or oncolytic adenovirus strategy. NcRNA-guided nanoparticles strategies primarily include self-assembled oligonucleotide nanoparticles, LNPs, inorganic nanoparticles, and polymeric nanoparticles; ncRNA modification strategies primarily include RNAi, ASOs, LNAs, Morpholinos and CRISPR-associated system; and oncolytic adenovirus strategies primarily includes the use of Ad-shRNA. LNPs, lipid-based nanoparticles; RNAi, double stranded RNA-mediated interference; ASOs, single stranded antisense oligonucleotides; LNAs, locked nucleic acids; Ad-shRNA, adenovirus-shRNA. ncRNA, non-coding RNA; ROS, reactive oxygen species.