Table IV.
Summary of primary modulators of iron metabolism-related ncRNAs involved in ferroptosis.
| First author, year | Gene | Function | ncRNA | Modulatory Effect | (Refs.) |
|---|---|---|---|---|---|
| Jiang et al, 2020 | ACSL4 | Converts free fatty acids into fatty acyl-CoAs | miR-34a-5p/miR-204-5p | Suppresses the expression of ACSL4 directly | (85) |
| Park et al, 2018 | miR-141 | (86) | |||
| Wu et al, 2018 | miR-3595 | (87) | |||
| Bai et al, 2017; Ooi J et al, 2017 | miR-34a/c | (88,89) | |||
| Zhou et al, 2017 | miR-548p | (90) | |||
| Cui et al, 2014 | miR-205 | (91) | |||
| Peng et al, 2013 | miR-224-5p | (92) | |||
| Park et al, 2018 | miR-19b-3p/miR-17-5p/miR-130a-3p/miR-150-5p/miR-7a-5p/miR-144-3p/miR-16-5p | (93) | |||
| Jiang et al, 2020 | NEAT1 | Promotes the expression of ACSL4 by completing miR-34a-5p and miR-204-5p | (85) | ||
| Li et al, 2019 | LOXs | Catalyzes the dioxygenation of polyunsaturated fatty acids in lipids | miR-18a/miR-203 | Suppresses the expression of 15-LOX1 directly | (96) |
| Li et al, 2019 | miR-17/miR-20a/miR-20b/miR-106a/miR-106b/miR-93/miR-590-3p | Suppresses the expression of 15-LOX2 directly | (96) | ||
| Fredman et al, 2012 | miR-219-2 | Suppresses the expression of 15-LOX directly | (97) | ||
| Su et al, 2016 | miR-674-5p | Suppresses the expression of 5-LOX directly | (98) | ||
| Wang et al, 2018 | miR-216a-3p | (99) | |||
| Busch S et al, 2015 | miR-19a-3p/miR-125b-5p | (100) | |||
| Xue et al, 2018; Min et al, 2018 | GPX4 | Lipid repair enzyme | miR-181a-5p | Decreases protein expression of GPX4 by targeting SBP2 or SECISBP2 | (101,102) |
| Zhang et al, 2017 | SCD1 | Converts the saturated fatty acids palmitate and stearate to the monounsaturated fatty acids palmitoleate PMA and oleate | miR-27a | Suppresses the expression of SCD1 directly | (104) |
| Guo et al, 2017 | miR-212-5p | (105) | |||
| Zhang et al, 2020 | miR-103 | (106) | |||
| Mysore et al, 2016 | miR-192* | (107) | |||
| Zhang et al, 2016 | miR-378 | (108) | |||
| Guo et al, 2018 | miR-4668 | (109) | |||
| El et al, 2017 | miR-600 | (110) | |||
| Zhou et al, 2019 | miR-Let-7c | (111) | |||
| Guo et al, 2018 | uc.372 | Promotes the expression of SCD1 by completing miR-4668 | (109) | ||
| Zeng et al, 2016; Pinto et al, 2017 | CS | Regulates the metabolism of mitochondrial fatty acid | miR-122/ miR-19 | Suppresses the expression of SCD1 directly | (112,113) |
ncRNA, non-coding RNA; miR, microRNA; ACSL4, acyl-CoA synthetase long-chain family member 4; GPX4, glutathione peroxidase 4; SCD1, stearoyl-CoA desaturase 1; CS, citrate synthase.