Table V.
Summary of primary modulators of antioxidant metabolism-related ncRNAs involved in ferroptosis.
| First author, year | Gene | Function | ncRNA | Modulatory Effect | (Refs.) |
|---|---|---|---|---|---|
| Luo et al, 2019; Zhao et al, 2019 | Nrf2 | Key regulator of anti-oxidant related genes expression | miR-675/miR-181 | Suppresses Nrf2 signaling | (114,115) |
| Zhang et al, 2019 | miR-302b-3p | Suppresses Nrf2 signaling by directly geting FGF15 | (116) | ||
| Wu et al, 2018; Zhou et al, 2019 | miR-141 | Suppresses Nrf2 signaling by directly targeting Keap1 | (117,118) | ||
| Reziwan et al, 2019 | miR-1225 | (119) | |||
| Duan et al, 2019 | miR-25 | Suppresses Nrf2 signaling by directly targeting KLF2 | (120) | ||
| Zhao et al, 2019 | miR-128-3p | Suppresses Nrf2 pathway by targeting Sirt1 | (121) | ||
| Liu et al, 2019 | miR-19b | Suppresses Nrf2 pathway by targeting SIRT1 | (122) | ||
| Chen et al, 2019 | miR-125b | Suppresses Nrf2 pathway by targeting PRXL2A | (123) | ||
| Ling et al, 2018 | miR-494 | Suppresses Nrf2 pathway by targeting NQO1 | (134) | ||
| Gao et al, 2018 | miR-365 | Suppresses the expression of Nrf2 directly | (135) | ||
| Geng et al, 2018 | miR-495 | Activates Nrf2 signaling by directly targeting PSD-93 | (126) | ||
| Wang et al, 2018 | miR-136 | (127) | |||
| Huang et al, 2018 | miR-34a | (128) | |||
| Wu et al, 2019 | miR-340-5p | (129) | |||
| Zhang et al, 2020 | miR-125b | (130) | |||
| Qin et al, 2019; Dong et al, 2019 | miR-101-3p | (131,132) | |||
| Chen et al, 2019 | miR-155 | (133) | |||
| Cai et al, 2019 | miR-380-3p | (134) | |||
| Srinoun et al, 2019; Yin et al, 2018; Li et al, 2019 | miR-144 | (135–137) | |||
| Zhu et al, 2019 | miR-153 | (138) | |||
| Khadrawy et al, 2019 | miR-28/ miR-708 | (139) | |||
| Sun et al, 2019 | miR-129-3p | (140) | |||
| Huang et al, 2019 | miR-27b | (141) | |||
| Liu et al, 2019 | miR-140-5p | (142) | |||
| Singh et al, 2013 | miR-93 | (143) | |||
| Chorley et al, 2012 | miR-365-1/ miR-193b/ miR-29-b1 | (144) | |||
| Zhang et al, 2019 | miR-152-3p | Activates Nrf2 signaling by directly targeting PSD-93 | (145) | ||
| Kim et al, 2014 | miR-101 | Activates Nrf2 signaling by directly targeting Cul3 | (146) | ||
| Xu et al, 2017 | miR-455 | (147) | |||
| Chen et al, 2019 | miR-601 | (148) | |||
| Kabaria et al, 2015 | miR-7 | Activates Nrf2 signaling by targeting Keap1 | (149) | ||
| Eades et al, 2011 | miR-200a | (150) | |||
| Wang et al, 2019 | miR-873-5p | (151) | |||
| Xiao et al, 2018 | miR-24-3p | (152) | |||
| Huang et al, 2019 | miR-34b | (153) | |||
| Ding et al, 2019 | miR-223 | (154) | |||
| Li et al, 2019 | miR-146b-5p | Activates Nrf2 signaling by targeting Brd4 | (155) | ||
| Sun et al, 2018 | miR-98-5p | Activates Nrf2 signaling by targeting Bach1 | (156) | ||
| Feng et al, 2019 | Blnc1 | Activates Nrf2 signaling | (157) | ||
| Li et al, 2019; Fan et al, 2018; Chen et al, 2018; Amodio et al, 2018; Zeng et al, 2018 | MALAT1 | (158–162) | |||
| Joo et al, 2019 | Nrf2-lncRNA | (163) | |||
| Liu et al, 2019 | AK094457 | (164) | |||
| Porsch et al, 2019 | Linc01213 | (165) | |||
| Xiao X et al, 2019 | lncRNA 74.1 | (166) | |||
| Gao et al, 2017 | ODRUL | (167) | |||
| Dong et al, 2018 | SNHG14 | Activates Nrf2 signaling by directly targeting PABPC1 | (168) | ||
| Geng et al, 2018 | UCA1 | Increases the expression of Nrf2 by miR-495 | (126) | ||
| Luzon-Toro et al, 2019 | LUCAT1 | Increases the expression of Nrf2 | (169) | ||
| Sun et al, 2019; Zhang et al, 2019; Gong et al, 2019 | TUG1 | (170–172) | |||
| Wu et al, 2017 | Loc344887 | (173) | |||
| Zheng et al, 2016 | H19 | (174) | |||
| Li et al, 2016 | Mhrt | (175) | |||
| Zhou et al, 2015 | MIAT | (176) | |||
| Yuan et al, 2015 | MRAK052686 | (177) | |||
| Zhao et al, 2015 | AATBC | (178) | |||
| Zhang et al, 2015 | HOTAIR | (179) | |||
| Wu et al, 2019 | NRAL | Activates the expression of Nrf2 by miR-340-5p | (129) | ||
| Luo et al, 2019 | H19 | Suppresses Nrf2 signaling | (114) | ||
| Li et al, 2017 | Sox2OT | (180) | |||
| Gao et al, 2018 | MT1DP | Activates the expression of Nrf2 by miR-365 | (125) | ||
| Wang et al, 2018; Huang et al, 2018; Wang et al, 2017 | MEG3 | Activates the expression of Nrf2 by miR-136 or miR-34a | (127, 128, 181) | ||
| Wu et al, 2018 | KRAL | Activates Nrf2 signaling by directly targeting Keap1 | (117) | ||
| Li et al, 2020 | circ4099 | Activates Nrf2 signaling | (182) | ||
| Drayton et al, 2014 | SLC7A11 | Subunit of system Xc− to import cystine | miR-27a | Suppresses the expression of SLC7A11 directly | (183) |
| Wu et al, 2017 | miR-375 | (184) | |||
| Liu et al, 2011 | miR-26b | (185) | |||
| Luo et al, 2017 | SLC7A11-AS1 | Suppresses the expression of SLC7A11 | (186) | ||
| Yuan et al, 2017 | AS-SLC7A11 | (187) | |||
| Xian et al, 2020 | Keap1 | Binds to and regulates Nrf2 by keeping its levels | miR-26b | Suppresses the expression of Keap1 directly | (190) |
| Li et al, 2020 | miR-941 | (191) | |||
| Jiang et al, 2020; Wang et al, 2020 | miR-200a | (192,193) | |||
| Duan et al, 2019 | miR-421 | (194) | |||
| Xu et al, 2019 | miR-626 | (195) | |||
| Reziwan et al, 2019 | miR-1225 | (119) | |||
| Zhou et al, 2019 | miR-141 | (118) | |||
| Akdemir et al, 2017 | miR-432 | (196) | |||
| Amodio et al, 2018 | MALAT1 | Epigenetically regulates Keap1 | (161) | ||
| Wu et al, 2018 | KRAL | Activates Nrf2 signaling by completing with miR-141 | (127) | ||
| Zhang et al, 2018; Wang et al, 2019 | GOT1 | Synthesis of a-ketoglutarate from glutamate | miR-9 | Suppresses the expression of Keap1 directly | (57,198) |
ncRNA, non-coding RNA; miR, microRNA; nuclear factor erythroid 2-related factor 2; Keap1, kelch-like ECH-associated protein 1.