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. 2020 Nov 19;45(1):83–94. doi: 10.3892/or.2020.7859

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — YAP inhibition interrupts PDGF-BB-enhanced cancer malignancy. (A) Western blot analysis of YAP expression in BxPC-3 cells after treatment with 100 ng/ml PDGF-BB and increasing concentrations of verteporfin (0, 0.1, 0.5, 1 and 2 µM). MTT assay of cell proliferation after BxPC-3 cells were exposed to (B) increasing concentrations of verteporfin (0, 0.1, 0.5 and 1 µM) for 24 h and (C) 100 ng/ml PDGF-BB with or without 0.1 µM verteporfin for 24 h. (D) Analysis of cell apoptosis via flow cytometry of BxPC-3 cells exposed to 100 ng/ml PDGF-BB with or without 0.1 µM verteporfin and cultured in suspension for 48 h. (E) Percentage of apoptotic cells. (F) Wound-healing assays of BxPC-3 cells in the presence of 100 ng/ml PDGF-BB with or without 0.1 µM verteporfin for 24 h. (G) Wound-healing area in three independent experiments. Data are presented as the mean ± SD (n=3). *P<0.05 and **P<0.01. PDGF-BB, platelet-derived growth factor-BB; YAP, Yes-associated protein; Vert, verteporfin.