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. 2020 Nov 19;45(1):83–94. doi: 10.3892/or.2020.7859

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — YAP knockdown inhibits PDGF-BB-induced cancer malignancy. (A) Western blot analysis of YAP expression in BxPC-3 cells treated with YAP siRNAs for 48 h. (B) MTT assay of the proliferation of BxPC-3 cells exposed to 100 ng/ml PDGF-BB with or without YAP siRNA2 for 24 h. (C) Analysis of apoptosis via flow cytometry in BxPC-3 cells exposed to 100 ng/ml PDGF-BB with or without YAP siRNA and cultured in suspension for 48 h. (D) Percentage of apoptotic cells (E) Wound-healing assays on BxPC-3 cells in the presence of 100 ng/ml PDGF-BB with or without YAP siRNA for 24 h. (F) Wound-healing area in three independent experiments. Data are presented as the mean ± SD (n=3). *P<0.05 and **P<0.01 vs. PDGF. PDGF-BB, platelet-derived growth factor-BB; YAP, Yes-associated protein; si, small interfering; Ctrl, control.