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. 2020 Nov 19;45(1):83–94. doi: 10.3892/or.2020.7859

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Blockade of the RhoA/PP-1 cascade impairs PDGF-BB-induced YAP activation. (A) Western blot analysis of YAP expression and its phosphorylation at Ser127 in BxPC-3 cells treated with 100 ng/ml PDGF-BB with or without CP-673451 for 24 h. (B) Western blot analysis of YAP accumulation and phosphorylation in BxPC-3 cells treated with 100 ng/ml PDGF-BB with 30 µM Rhosin or 30 nM calyculin A for 24 h. (C) Relative firefly/Renilla luciferase activity in BxPC-3 cells transfected with the 8×GTIIC-luc reporter and cultured under PDGF-BB treatment together with 30 µM Rhosin or 30 µM calyculin A for 24 h. Data are presented as the mean ± SD (n=3). **P<0.01. PDGF-BB, platelet-derived growth factor-BB; YAP, Yes-associated protein; p, phosphorylated.