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. 2020 Nov 19;45(1):83–94. doi: 10.3892/or.2020.7859

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — PDGFR inhibition decreases YAP activity and cancer malignancy. (A) Western blot analysis of YAP expression in BxPC-3 cells after treatment with increasing concentrations of CP-673451 (0–100 nM) for 24 h. (B) RT-qPCR analysis of the expression levels of MYC and MCL-1 in BxPC-3 cells treated with 50 nM CP-673451 for 24 h. (C) Western blot analysis of E-cadherin and N-cadherin expression in BxPC-3 cells after CP-673451 treatment for 24 h. (D) RT-qPCR analysis of E-cadherin and N-cadherin expression in BxPC-3 cells. The results are presented as the average expression levels after normalization with GAPDH. (E) Flow cytometric analysis and (F) quantification of apoptosis in BxPC-3 cells after treatment with CP-673451 for 24 h. Data are presented as the mean ± SD (n=3). *P<0.05 and **P<0.01 vs. PBS/mock. PDGF-BB, platelet-derived growth factor-BB; YAP, Yes-associated protein; RT-qPCR, reverse transcription-quantitative PCR.