. 2020 Oct 20;184(1):167–178. doi: 10.1530/EJE-20-0073
This work is licensed under a Table 4.
Sensitivity and specificity of different aldosterone cut-offs after saline infusion measured by immunoassay.
| ALD, ng/L | TP, n | FP, n | TN, n | FN, n | SN (95% CI) | SP (95% CI) | +LR (95% CI) | -LR (95% CI) | +PV (95% CI) | -PV (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| >49 | 102 | 14 | 70 | 1 | 99.0 (94.7–100.0) | 83.3 (73.6–90.6) | 5.9 (3.7–9.6) | 0.01 (0.002–0.08) | 87.9 (81.9–92.2) | 98.6 (90.9–99.8) |
| >50 | 101 | 13 | 71 | 2 | 98.1 (93.2–99.8) | 84.5 (75.0–91.5) | 6.3 (3.8–10.5) | 0.02 (0.006–0.09) | 88.6 (82.5–92.8) | 97.3 (90.0–99.3) |
| >53 | 99 | 12 | 72 | 4 | 96.1 (90.4–98.9) | 85.7 (76.4–92.4) | 6.7 (4.0–11.4) | 0.05 (0.02–0.1) | 89.2 (83.0–93.3) | 94.7 (87.3–97.9) |
| >54 | 98 | 11 | 73 | 5 | 95.2 (89.0–98.4) | 86.9 (77.8–93.3) | 7.3 (4.2–12.6) | 0.06 (0.02–0.1) | 89.9 (83.7–93.9) | 93.6 (86.1–97.2) |
| >56 | 98 | 10 | 74 | 5 | 95.2 (89.0–98.4) | 88.1 (79.2–94.1) | 7.9 (4.5–14.3) | 0.06 (0.02–0.1) | 90.7 (84.5–94.6) | 93.7 (86.2–97.2) |
| >59 | 96 | 10 | 74 | 7 | 93.2 (86.5–97.2) | 88.1 (79.2–94.1) | 7.8 (4.4–14.0) | 0.08 (0.04–0.2) | 90.6 (84.3–94.5) | 91.4 (83.7–95.6) |
| >61 | 96 | 8 | 76 | 7 | 93.2 (86.5–97.2) | 90.5 (82.1–95.8) | 9.8 (5.1–19.0) | 0.08 (0.04–0.2) | 92.3 (86.1–95.9) | 91.6 (84.1–95.7) |
| >64 | 95 | 8 | 76 | 8 | 92.2 (85.3–96.6) | 90.5 (82.1–95.8) | 9.7 (5.0–18.8) | 0.09 (0.04–0.2) | 92.2 (86.0–95.8) | 90.5 (83.0–94.9) |
| >68 | 93 | 8 | 76 | 10 | 90.3 (82.9–95.2) | 90.5 (82.1–95.8) | 9.5 (4.9–18.4) | 0.11 (0.06–0.2) | 92.1 (85.7–95.8) | 88.4 (80.8–93.2) |
| >80 | 84 | 7 | 77 | 19 | 81.6 (72.7–88.5) | 91.7 (83.6–96.6) | 9.8 (4.8–20.0) | 0.20 (0.1–0.3) | 92.3 (85.4–96.1) | 80.2 (72.9–85.9) |
| >90 | 76 | 6 | 78 | 27 | 73.8 (64.2–82.0) | 92.9 (85.1–97.3) | 10.3 (4.7–22.5) | 0.28 (0.2–0.4) | 92.7 (85.3–96.5) | 74.3 (67.5–80.1) |
| >130 | 57 | 4 | 80 | 46 | 55.3 (45.2–65.1) | 95.2 (88.3–98.7) | 11.6 (4.4–30.7) | 0.47 (0.4–0.6) | 93.4 (84.4–97.4) | 63.5 (58.3–68.4) |
| >171 | 41 | 2 | 82 | 62 | 39.8 (30.3–49.9) | 97.6 (91.7–99.7) | 16.7 (4.2–67.1) | 0.62 (0.5–0.7) | 95.3 (83.6–98.8) | 56.9 (53.0–60.8) |
| >200 | 29 | 0 | 84 | 74 | 28.2 (19.7–37.9) | 100.0 (95.7–100.0) | - | 0.72 (0.6–0.8) | 100.0 | 53.2 (50.1–56.2) |
+LR, positive likelihood ratio; −LR, negative likelihood ratio; FN, false negatives; FP, false positives; +PV, positive predictive value; −PV, negative predictive value, SN, sensitivity; SP, specificity; TN, true negatives; TP, true positives.