. 2020 Oct 23;2(1):R115–R128. doi: 10.1530/VB-20-0012
This work is licensed under a Table 2.
miR-145 targets in cancer that are present in cardiovascular cell types.
| Target genes | Cardiovascular cell type | Type of cancer | References |
|---|---|---|---|
| OCT4 (POU5F1) | SMC, perivascular cells | LSCC, cervical, NSCLC | (42, 43, 48, 86, 87) |
| SOX2 | EC | Colorectal, LSCC, cervical | (32, 42, 43, 92) |
| KLF4 | SMC | LSCC, cervical, bladder | (8, 42, 43, 49) |
| NANOG | SMC | Cervical | (43, 88) |
| c-MYC (MYC) | Cardiomyocytes | Breast, prostrate, colon, NSCLC | (44, 46, 47, 103) |
| PAI1 (SERPINE1) | SMC | Bladder | (50, 84) |
| p70S6K1 | EC | Colon | (53, 58) |
| DDX17 (p72) | Cardiomyocytes | Colon | (52, 106) |
| MUC1 | EC | Lung | (61, 91) |
| SMAD3 | Fibroblasts, cardiomyocytes | Nasopharyngeal | (63, 100) |
| HOXA1 | Cardiac neural crest cells | Oral (OSCC) | (65, 104) |
| FSCN1 | EC | Lung (NSCLC), breast | (70, 71, 90) |
| JAMA (F11R) | EC, leukocytes | Breast | (69, 72, 108) |
| N-RAS | EC, SMC | Breast, colorectal | (30, 54, 84, 97) |
| VEGFA | EC | Breast | (30, 95, 96) |
| PAK1 | Cardiomyocytes, EC | Bladder, breast | (66, 67, 93, 94) |
| PAK4 | Cardiomyocytes, EC | Colon | (55, 93, 94) |
| IRS1 | EC | Colorectal | (54, 98) |
| N-CADHERIN | EC | Lung | (74, 75) |
| ADAM17 | EC, SMC, fibroblasts | Renal | (59, 102) |
| ROCK1 | SMC | Breast | (73, 85) |
EC, endothelial cells; LSCC, laryngeal squamous cell carcinoma; NSCLC, non-small cell lung cancer; OSCC, oral squamous cell carcinoma; SMC, smooth muscle cells.