TABLE 1.
Fezolinetant | ||||||||
Parameters | Placebo (n = 43) | 15 mg BID (n = 45) | 30 mg BID (n = 43) | 60 mg BID (n = 45) | 90 mg BID (n = 44) | 30 mg QD (n = 43) | 60 mg QD (n = 45) | 120 mg QD (n = 44) |
MENQoL, n | 43 | 45 | 43 | 45 | 42 | 42 | 44 | 44 |
Overall score | 4.3 (1.6) | 4.1 (1.3) | 4.0 (1.3) | 4.1 (1.5) | 4.1 (1.3) | 4.4 (1.5) | 4.2 (1.5) | 4.1 (1.3) |
HFRDIS, n | 43 | 45 | 43 | 45 | 42 | 42 | 44 | 44 |
Overall mean score | 6.0 (2.3) | 5.4 (2.0) | 5.4 (2.1) | 5.6 (2.3) | 5.1 (2.3) | 6.0 (2.1) | 5.3 (2.3) | 5.7 (2.3) |
GCS, n | 43 | 45 | 43 | 44 | 42 | 43 | 44 | 44 |
Overall sum | 21.7 (10.3) | 19.6 (8.2) | 17.6 (10.1) | 19.8 (12.0) | 17.8 (10.3) | 20.5 (9.1) | 19.3 (9.3) | 19.4 (10.4) |
Data are means (standard deviations).
GCS, Greene climacteric scale; HFRDIS, hot flash related daily interference scale; MENQoL, menopause-specific quality of life.