Skip to main content
. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Cell Chem Biol. 2020 Aug 13;27(10):1241–1249.e4. doi: 10.1016/j.chembiol.2020.07.021

Figure 4.

Figure 4.

Co-crystal structures of the ZTP riboswitch bound to 1-pyridinyl-AICA analogs. (a) View of the ligand binding site of the ZTP riboswitch bound to ZMP (yellow) (Jones and Ferré-D’Amaré, 2015). (b) View of the ligand binding site of the ZTP riboswitch bound to 7 (yellow) with nearby base pair G17:C69 and ligand-contacting residues U70 and G71 (orange) and G63 (magenta). The ∣Fo∣-∣Fc∣ Fourier difference map prior to ligand placement is shown, contoured at 3 σ (green mesh). (c) Similar view of the ligand binding site for the ZTP riboswitch bound to 13 (yellow). Black dotted line denotes a putative hydrogen bond (3.0 Å) between the pyridine and G63.