Table 1.

Isothermal titration calorimetry measurements for AICA analogs

Compound	Kd, μM	ΔH, kcal mol−1
1	0.32 ± 0.13	−9 ± 5
2	41 ± 4	−17 ± 2
5	2.3 ± 0.6	−27 ± 3
7a	1.0 ± 0.3	−19 ± 2
7b	1.4 ± 0.2	−22 ± 2
8a	11 ± 1	−17.1 ± 0.5
8b	8.7 ± 1.4	−15 ± 6
10	150 ± 30	−16 ± 2
12	5.6 ± 3.2	−20 ± 5
13	0.60 ± 0.06	−24 ± 8

^aCommercially obtained compound.

^bSynthesized compound.

Values are the mean ± standard deviation, with n = 3 independent experiments for all compounds except 7, for which n = 6.