Figure 3.

A hypothetic model to illustrate senotherapy‐mediated healthy aging. The first stage of the survival curve refers to the pre‐mortality plateau phase (PPP), during which ≈10% of the overall population is lost over a relatively long period. Alternatively referred to as a healthy lifespan, the PPP covers three sub‐stages, including an adolescent period when the body actively develops, a young adult period when the individual is physiologically mature, and a middle‐aged period when the mortality rate begins to increase. During the overall PPP span, 90% of the population remains alive, after which the mortality rate significantly arises and the population declines rapidly, a period constituting the late‐aged phase. However, in the case of senotherapy which theoretically comprises multiple waves of medications with senolytics administered in an intermittent or metronomic manner, the lifespan can be remarkably extended. Senotherapy can eliminate senescent cells, promote tissue repair, improve organ regeneration, and ameliorate multiple age‐related pathologies, thus providing a prominent avenue for a healthier aging of human populations.^{[ 165} , ^{166 ]}