Table 2.

Examples of agents that show senolytic or senomorphic activity

Agent	Source	Target (s)	References
Senolytics
ABT263 (Navitoclax)	Synthetic	Bcl‐xL, Bcl‐2, Bcl‐W	[ 39 , 40 ]
ABT737	Synthetic	Bcl‐xL, Bcl‐2, Bcl‐W	[ 35 ]
A1331852	Synthetic	BCL‐xL	[ 42 ]
A1155463	Synthetic	BCL‐xL	[ 42 ]
UBX0101	Synthetic	MDM2	[ 33 ]
Ouabain	Natural (plants)	Na+/K+‐ATPase	[ 54 ]
Cardiac glycosides (Proscillaridin A, Digoxin, etc.)	Natural (plants)	Na+/K+‐ATPase	[ 153 ]
Quercetin	Natural (Vegetables, dietary Supplements)	PI3K/Akt, p53	[ 36 , 67 , 72 , 76 ]
Dasatinib	Synthetic	Src family tyrosine kinases (BCR/ABL, Src, c‐Kit, ephrin)	[ 36 , 67 , 72 , 76 ]
Curcumin	Natural (plants)	Nrf2, NF‐κB (p65)	[ 154 ]
o‐Vanillin (curcumin metabolite)	Natural (plants)	Nrf2, NF‐κB (p65)	[ 154 ]
EF24 (curcumin analog)	Synthetic	Bcl‐xL, Mcl‐1	[ 155 ]
Fisetin	Natural (plants, fruits, dietary supplements)	Sirtuins	[ 156 ]
Piperlongumine	Natural (piper plants)	Caspase 3	[ 58 ]
FOXO4‐DRI peptide	Synthetic	FOXO4‐p53 interaction	[ 48 ]
Alvespimycin (17‐DMAG)	Synthetic (geldanamycin derivative)	HSP90	[ 47 ]
Senomorphics
Apigenin	Natural (plants, fruits, vegetables, tea)	NF‐κB	[ 94 ]
Kaempferol	Natural (fruits, vegetables)	NF‐κB	[ 94 ]
Glucosamine	Natural (Dietary supplements)	ROS, p21CIP1, autophagy	[ 157 , 158 ]
Nordihydroguaiaretic acid (NDGA)	Natural (Creosote bush)	p300 acetyltransferase	[ 97 ]
Resveratrol	Natural (fruits, red wine, dietary supplements)	SIRT1	[ 159 , 160 ]
Rapamycin	S. hygroscopicus	mTOR	[ 103 , 104 ]
Metformin	Synthetic	AMPK	[ 161 , 162 ]
Ruxolitinib	Synthetic	JAK1/2	[ 163 ]
SB203580	Synthetic	p38MARPK	[ 101 ]
5Z‐7‐oxozeaenol	Synthetic	TAK1	[ 106 ]