Table 9. Overview of p-values with the sixth passage as reference.

Passage	Number of brain metastases		Total volume of brain metastases		Average volume of brain metastases		Number of affected bones
	Week 3	Week 4	Week 3	Week 4	Week 3	Week 4	Week 4
1	<0.001	0.461	<0.001	<0.001	<0.001	<0.001
2	<0.001	<0.001	<0.001	<0.001	0.001	<0.001
3	0.461	<0.001	0.171	0.541	0.079	0.003
4	0.051	0.641	0.359	0.735	0.887	0.682
5	0.813	0.299	0.953	0.979	0.656	0.562
6
Evolution	Sign. increase (0.01)		Sign. increase (0.007)	Sign. increase (<0.001)	Sign. increase (<0.001)	Sign. increase (<0.001)	Sign. decrease (0.048)