Table 1. Clinical outcomes by group.
| Cohort 1 | Cohort 2- Naive | Cohort 2- Veteran | ||||
|---|---|---|---|---|---|---|
| Target Dose (cfu) | 1.0x108 | 1.0x109 | 1.0x109 | 1.0x1010 | 1.0x109 | 1.0x109 |
| Actual Dose (cfu) | 1.66x108 | 1.90x109 | 1.90x109 | 1.97x1010 | 1.90x109 | 1.90x109 |
| Fasting Time | Overnight | 90 min | Overnight | 90 min | Overnight | Overnight |
| MSD (any) | 3/7 (42.9%) | 3/7 (42.9%) | 5/7 (71.4%) | 5/7 (71.4%) | 11/19 (57.9%) | 5/11 (45.5%) |
| MSD (by vol) | 3/7 (42.9%) | 3/7 (42.9%) | 5/7 (71.4%) | 5/7 (71.4%) | 11/19 (57.9%) | 5/11 (45.5%) |
| MSD (by num) | 3/7 (42.9%) | 2/7 (28.6%) | 4/7 (57.1%) | 5/7 (71.4%) | 10/19 (52.6%) | 4/11 (36.4%) |
| Max 24 hr vol, median (IQR) | 263 (0, 1366) | 252 (0, 1046) | 1055 (380, 1339) | 607 (247, 708) | 504 (135, 766) | 303 (0, 1016) |
| Max 24 hr num, median (IQR) | 3 (0, 6.0) | 1 (0, 13) | 8 (2, 10) | 5 (2, 10) | 5 (1, 6) | 3 (0, 6) |
| Onset time (h), median (IQR) | 31.0 (16.0, 46.0) | 11.4 (11.2, 13.4) | 18.5 (13.0, 21.4) | 24.8 (12.0, 43.1) | 14.2 (9.5, 17.4) | 12.8 (5.2, 18.7) |
| MSD time (h), median (IQR) | 36.1 (21.0, 80.2) | 22.6 (16.0, 70.8) | 28.8 (20.2, 29.1) | 34.5 (26.4, 66.9) | 24.7 (13.6, 32.6) | 23.1 (19.9, 24.1) |
| IV therapy | 2/7 (28.6%) | 2/7 (28.6%) | 6/7 (85.7%) | 3/7 (42.9%) | 8/19 (42.1%) | 2/11 (18.2%) |
| Early abx | 3/7 (42.9%) | 3/7 (42.9%) | 4/7 (57.1%) | 4/7 (57.1%) | 10/19 (52.6%) | 4/11 (36.4%) |
cfu: colony forming units.
MSD: moderate to severe diarrhea.
Max 24 hr vol: maximum 24 hour volume of loose/liquid stools.
Max 24 hr num: maximum number of loose/liquid stools in 24 hour period.
IQR: interquartile range.
Abx: antibiotics.