Table 2. Frequency of adverse events by group.
| Group 1 | Group 2 | Group 3 | Group 4 | Naïve | Veteran | |
|---|---|---|---|---|---|---|
| Dose | 108 | 109 | 109 | 1010 | 109 | 109 |
| Fasting | Overnight | 90 minutes | Overnight | 90 minutes | Overnight | Overnight |
| N | 7 | 7 | 7 | 7 | 19 | 11 |
| Abdominal cramps, n (%) | 5 (71.4) | 5 (71.4) | 5 (71.4) | 3 (42.9) | 13 (68.4) | 7 (63.6) |
| Abdominal Pain, n (%) | 3 (42.9) | 4 (57.1) | 5 (71.4) | 5 (71.4) | 12 (63.2) | 7 (63.6) |
| Abdominal Tenderness, n (%) | 0 (0.0) | 0 (0.0) | 2 (28.9) | 0 (0.0) | 9 (47.4) | 2 (18.2) |
| Anorexia, n (%) | 4 (57.1) | 4 (57.1) | 5 (71.4) | 4 (57.1) | 14 (73.7) | 4 (36.4) |
| Arthralgia, n (%) | 0 (0.0) | 1 (14.3) | 0 (0.0) | 1 (14.3) | 3 (15.8) | 1 (9.1) |
| Bloating, n (%) | 5 (71.4) | 6 (85.7) | 5 (71.4) | 4 (57.1) | 11 (57.9) | 5 (45.5) |
| Constipation, n (%) | 1 (14.3) | 1 (14.3) | 2 (28.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Fever, n (%) | 0 (0.0) | 0 (0.0) | 1 (14.3) | 0 (0.0) | 3 (15.8) | 1 (9.1) |
| Flatulence, n (%) | 7 (100.0) | 6 (85.7) | 6 (85.7) | 4 (57.1) | 10 (52.6) | 7 (63.6) |
| Generalized Myalgia, n (%) | 0 (0.0) | 1 (14.3) | 0 (0.0) | 1 (14.3) | 3 (15.8) | 2 (18.2) |
| Headache, n (%) | 3 (42.9) | 4(57.1) | 3 (42.9) | 5 (71.4) | 10 (52.6) | 4 (36.4) |
| Hyperactive Bowel Sounds, n (%) | 5 (71.4) | 2 (28.9) | 7 (100.0) | 3 (42.9) | 8 (42.1) | 3 (27.3) |