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Proposed model for different RNF146 and TNKS substrates. Proteins are poly-ADP-ribosylated by TNKS1/2, or other poly-ADP-ribose polymerase, or mono-ADP-ribosylated by PARP10 then poly-ADP-ribosylated. Those poly-ADP-ribosylated protein are recognized and ubiquitylated by RNF146. RNF146 can make two type ubiquitination, K48 and K63-linked ubiquitination. Proteins with K48-linked ubiquitination are subjected to degradation, like PARP10, OTUD5 and SARDH in this study.
