Table I. Gene expression and protein abundance of the selected candidates in all study phases. *BAG5 and SRGAP2 replication was conducted using independent western blot experiments, so p-values are not adjusted for multiple comparisons (supplemental Fig. S4). Significant p-values are indicated in bold, ^#indicates p < 0.1.

	Discovery phase-2 h after MCAO-			Replication phase-2 h after MCAO-			Exploration over time-6 h after MCAO-			2 h versus 6 h
	Fold change (IP/CL)	Raw p-value	Adj. p-value	Fold change (IP/CL)	Raw p-value	Adj. p-value	Fold change (IP/CL)	Raw p-value	Adj. p-value	Raw p-value	Adj. p-value
Gene expression
4933427D14Rik	0.341	0.045	0.999	0.865	0.011	0.017	0.942	0.360	0.390	0.338	0.440
Atf3	27.44	<0.001	0.167	7.603	0.002	0.006	14.230	<0.001	0.002	0.198	0.286
Ccl3	161.32	<0.001	0.027	9.012	<0.001	0.001	10.130	0.027	0.050	0.849	0.849
Cldn20	0.216	0.007	0.999	0.494	0.004	0.007	0.845	0.094#	0.135	0.012	0.099#
Cstad	0.352	0.034	0.999	0.498	0.004	0.007	0.456	0.001	0.002	0.580	0.685
Fosb	45.74	<0.001	0.793	7.407	<0.001	0.001	6.349	0.002	0.006	0.683	0.740
Gadd45g	20.06	0.005	0.999	4.010	<0.001	0.001	2.129	<0.001	0.001	0.015	0.099#
Gata2	0.319	0.017	0.999	0.775	0.118	0.171	1.053	0.893	0.893	0.134	0.235
Il1r1	0.299	0.029	0.999	0.882	0.233	0.275	1.145	0.350	0.390	0.125	0.235
Intu	0.384	0.039	0.999	0.937	0.422	0.457	1.158	0.249	0.324	0.145	0.235
Rgs2	43.38	0.008	0.999	3.922	0.002	0.005	2.721	<0.001	0.001	0.074#	0.235
Zfand4	0.308	0.027	0.999	0.997	0.196	0.254	0.620	0.007	0.014	0.125	0.235
Protein abundance
Bag5*	0.761	<0.001	0.042	0.776	0.048	–	0.558	<0.001	–	0.096#	–
Ctnnd2	0.921	0.001	0.220	0.778	0.028	0.084#	0.960	0.457	0.686	0.054#	0.162
Camk2a	0.826	0.001	0.219	0.772	0.120	0.180	0.837	0.124	0.372	0.708	0.708
Srgap2*	1.089	0.007	0.474	1.088	0.597	–	0.784	0.123	–	0.159	–
Txn2	2.851	0.011	0.489	1.013	0.826	0.826	1.015	0.989	0.989	0.629	0.708