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. 2020 Dec 1;11(12):e00229. doi: 10.14309/ctg.0000000000000229

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — BA delivery system. The delivery system comprises 2 layers. (a) After disintegration of the Eudragit S100 coating, the system first releases a small dose immediately. This dose establishes a prosecretory and prokinetic BA level around the delivery system, facilitating further release from the controlled release layer. (b) The comparison of a (i) dissected pill and a (ii) dissected pill which was exposed to water for 5 minutes is shown to demonstrate the biphasic kinetic profile of this delivery approach. BA, bile acid.