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. 2020 Dec 1;11(12):e00229. doi: 10.14309/ctg.0000000000000229

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — In vivo evaluation of CDC bilayer delivery systems as compared to the capsule formulation (used in a clinical frontrunner study and linked to a high frequency of abdominal pain (9)). (a) Kaplan-Meier plot demonstrating the bilayer delivery system's capacity to maintain integrity throughout intestinal passage in swine. The results are shown in comparison to small intestinal transit time in man (1) (21). (b) Shows retrieved dissected delivery systems after 4 hours. (c) Representative rectal manometry patterns after rectal placement of uncoated bilayer delivery systems or CDC capsules. Amplitudes of 3 rectal manometry patterns are shown in (d). Giant contractions are indicated by arrowheads (data normalized to the mean amplitude). CDC, sodium chenodeoxycholate.