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. 2020 Nov 5;5(21):e137474. doi: 10.1172/jci.insight.137474

Figure 5. ACA reduces hepatic lipidosis and alters the hepatic lipidome similarly in both sexes.

Figure 5

(A and B) Liver pathology scores are from 25-month-old mice, with each dot representing a data point for an individual animals. (C–G) Lipidomics was conducted on 12-month-old animals. Sample sizes for lipidomic analysis were 7 female controls, 10 ACA females, 9 male controls, and 9 ACA males. (C) Heatmap of TAG species significantly changed in abundance with ACA treatment after correction for FDR. Each row represents a different TAG species, with rows ordered according to the chain length of each species (every fifth row labeled). Values for each species have been standardized before plotting, showing the number of SDs that each observation falls above or below the mean. Each column represents a value for a different mouse. (D) Changes in phosphatidylcholines in ACA-treated mice. Each row represents an individual species that differs in abundance with ACA treatment, with rows ordered according to number of double bonds. (E–G) Lysophosphatidylcholines (LPC), Lysophosphatidylethanolamines (LPE) (E), fatty acids (F), and sphingolipids (G) significantly altered in abundance with ACA treatment. Statistics calculated with a 2-way ANOVA, including sex and treatment as variables.