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. 2020 Nov 5;5(21):e140495. doi: 10.1172/jci.insight.140495

Figure 1. Developmental phenotypes in KrasT58I/+ mice.

Figure 1

(A) Growth curves of WT and KrasT58I/+ littermates on a mixed B6/129 strain background: WT male mice (n = 22); WT female mice (n = 20); KrasT58I/+ male mice (n = 11); KrasT58I/+ female mice (n = 20). Error bars represent mean ± SEM. Statistical significance was evaluated by Student’s t test. **P < 0.01. (B) Typical facial morphology of WT and KrasT58I/+ male mice. (C) Micro-CT imaging of the skulls from WT and KrasT58I/+ male mice at 8 months of age, showing craniosynostosis of the interfrontal and coronal sutures in mutant animals. Scale bar: 10 mm (top); original magnification, ×2.87 (bottom).