Figure 3.

gp100-reactive T cells reduce LAM-like lung tumors in mice. The number and size of tumor nodules developing in the presence or absence of gp100-reactive T cells were measured in vivo. (A) The experimental design for a LAM-like tumor challenge and adoptive transfer of transgenic CD3 T cells is shown. Mice were killed after 42 days. (B) Surface lung nodules were counted and additionally quantified as percentage of lung area (represented as mean ± SD), and (C) representative lung images are shown for each treatment group. N = 4. *P < 0.05 (Kruskall-Wallis test with Dunn’s multiple comparisons test). WT = wild type.