Table 6.

Binding energies of GGQL's key components to the target gene molecules.

Key components	Binding energies (kcal/mol)
	MMP3	IL1B	NOS2	HMOX1	PPARG	PLAU	MMP1	MMP9	COCL10	COL1A1	COL3A1	SPP1
Stigmasterol	−10.3	−8.78	−8.75	−8.04	−7.64	−7.25	−7.22	−6.94	−5.94	−6.32	−6.06	−6.9
Coptisine	−9.27	−7.97	−6.97	−6.27	−6.79	−6.59	−6.58	−6.73	−4.57	−6.31	−6.46	−6.16
Berberine	−9.81	−7.71	−6.92	−6.36	−6.57	−7.29	−6.81	−6.43	−4.84	−5.63	−5.89	−6.01
Liquiritigenin	−8.63	−7.95	−6.39	−6.04	−7.06	−7.41	−5.61	−7.58	−5.88	−5.89	−5.77	−4.31
Quercetin	−7.73	−8.45	−5.04	−5.2	−5.55	−7.17	−5.44	−5.05	−4.67	−3.92	−4.26	−5.09
Kaempferol	−8.37	−7.89	−5.82	−6.59	−6.2	−6.7	−4.79	−5.09	−5.38	−4.03	−5.37	−5.16
Wogonin	−8.96	−7.42	−5.98	−6.23	−5.91	−6.89	−4.74	−5.72	−4.48	−4.9	−5.22	−5.34
Baicalein	−8.41	−7.23	−6.59	−5.27	−6.67	−7.28	−5.65	−7.12	−5.19	−4.62	−6.16	−5.57
Puerarin	−6.46	−7.19	−4.95	−4.77	−4.93	−4.43	−4.07	−3.37	−2.73	−3.28	−4.39	−3.92
Daidzin	−8.7	−6.76	−6.33	−4.15	−4.52	−6.01	−4.27	−6.65	−4.07	−3.4	−4.56	−4.67
Epiberberine	−8.54	−7.38	−7.31	−6.19	−6.24	−6.19	−6.25	−6.83	−4.62	−6.12	−5.82	−5.53
Jatrorrhizine	−7.54	−7.46	−5.88	−5.01	−6.02	−5.44	−5.17	−5.92	−4.36	−5.1	−4.45	−4.98
Baicalin	−5.76	−6.69	−4.69	−3.49	−4.52	−4.22	−4.52	−2.41	−2.98	−2.98	−4.29	−3.82
Palmatine	−7.75	−6.8	−5.89	−5.81	−4.97	−5.76	−6.36	−5.55	−3.9	−5.23	−5.68	−5.3
Wogonoside	−7.68	−8.5	−5.99	−4.83	−5.22	−6.5	−4.73	−3.13	−5.36	−3.38	−4.49	−5.53