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. 2020 Nov 25;2020:8838524. doi: 10.1155/2020/8838524

Figure 1.

Figure 1

lncRNA-miRNA-mRNA axes in ischaemia/reperfusion injury. lncRNA-miRNA-mRNA axes regulating the pathogenesis of ischemia/reperfusion injury are shown, which are associated with cell apoptosis, autophagy, and proliferation, as well as inflammation and others. Colors in the boxes represent different organs. Colors in lines mean that different lncRNAs target their corresponding miRNAs and mRNAs. Abbreviations: lncRNA: long noncoding RNA; miRNAs: microRNAs; Rian: RNA imprinted and accumulated in nucleus; HIF1A-AS1: hypoxia inducible factor 1α-antisense RNA 1; MALAT1: metastasis-associated lung adenocarcinoma transcript 1; TUG1: taurine-upregulated gene 1; Mbd2: methyl-CpG-binding domain protein 2; APF: autophagy-promoting factor; GAS5: growth arrest specific 5; MEG3: maternally expressed gene 3; CHRF: cardiac hypertrophy-related factor; HOTAIR: HOX transcript antisense RNA; NLRC5: nucleotide-binding and oligomerization domain-like receptor C5; AKT: protein kinase B; PDCD4: programmed cell death 4; PTGS2: prostaglandin-endoperoxide synthase 2; NLRP3: Nod-like receptor protein-3; BNIP3: Bcl2 19 kDa protein-interacting protein 3; SOCS2: suppressor of cytokine signaling 2; HDAC3: histone deacetylase 3; HMGB1: high-mobility group box 1; Rac1: Ras-related C3 botulinum toxin substrate 1; GATA3: GATA-binding protein 3; ULK2: Unc-51-like kinase 2; AQP4: aquaporin 4; TRPV4: transient receptor potential vanilloid 4; SPRR2F: small proline-rich protein 2F; SPRR1A: small proline-rich protein 1A; MMP-10: matrix metalloproteinase-10; HMGB1: high-mobility group box 1; MMP-2/8: matrix metalloproteinase-2/8; Bcl2: B-cell lymphoma-2; Traf3: tumor necrosis factor (TNF) receptor-associated factor 3; PDCD4: programmed cell death 4; TSP-1: thrombospondin 1; PI3K: phosphatidylinositol 3 kinase; FADD: Fas-associated protein with death domain; cIAP1: cellular inhibitor of apoptosis protein 1; PARP1: poly(ADP-ribose) polymerase 1; PPARα: peroxisome proliferator-activated receptor α; Cab39: calcium-binding protein 39; ZO-1: zonula occludens 1; Rock2: rho-associated protein kinase 2; Id2: inhibitor of DNA binding/differentiation 2; AIM2: absent in melanoma 2; SOX6: sex-determining region Y box 6; Nrf2: nuclear factor erythroid 2-related factor; UCA1: urothelial carcinoma-associated 1; NEAT1: nuclear paraspeckle assembly transcript 1; HULC: highly upregulated in liver cancer; XIST: X chromosome inactivation; FTX: five prime to Xist; SNHG1/12/14/16: small nucleolar RNA host gene 1/12/14/16; RMRP: mitochondrial RNA-processing endoribonuclease; PINT: p53-induced transcript; NRF: necrosis-related factor; OIP5-AS1: Opa-interacting protein 5-antisense transcript 1; CARL: cardiac apoptosis-related lncRNA; MDRL: mitochondrial dynamic-related lncRNA; KCNQ1OT1: KCNQ1 opposite strand/antisense transcript 1; CasC7: cancer susceptibility candidate 7; HSP70: heat shock protein70; MAPK6: mitogen-activated protein kinase 6; ATG3/7/12: autophagy-related gene 3/7/12; PINK1: PTEN-induced putative kinase 1; Bcl2l2/12: B-cell lymphoma-2-like 2/12; IL-1β: interleukin-1β; HIF-1α: hypoxia inducible factor-1α; VEGF: vascular endothelial growth factor; Fmr1: fragile X mental retardation 1; OSMR: oncostatin M receptor β; SIRT1: sirtuin 1; LIMK1: the LIM motif-containing protein kinase family-contained LIM kinase 1; ROCK1: rho-associated coiled-coil-containing protein kinase 1; FOXO3/4: forkhead box O3/4; CK: creatine kinase; CM-MB: creatine kinase MB form; LDH: lactate dehydrogenase; TRAF6: TNF receptor-associated factor 6; CSE: cystathionine-γ-lyase; RIPK 1/3: receptor-interacting serine/threonine-protein kinase 1/3; AMPK: adenosine monophosphate-activated protein kinase; PGC1α: peroxlsome proliferator-activated receptor-γ coactlvator-1α; PHB2: prohibitin 2; LGALS3: galectin-3; DAPK1: death-associated protein kinase 1; NR3C2: nuclear receptor subfamily 3 group C member 2; CHOP: C/EBP homologous protein.