Table 3.
Irisin and cytokines concentration (pg/mL) in children with NW, MHO, and MUO.
| NW (n = 34) | MHO (n = 36) | MUO (n = 44) | p value | |
|---|---|---|---|---|
| Irisin | 8.05 (7.3-8.95) | 6.15 (4.1-6.9)∗ | 6.4 (5.8-7)∗ | <0.0001 |
| IL-1β | 0.3 (ND-0.3) | 0.3 (0.3-0.3) | 0.3 (0.3-0.55) | 0.5897 |
| IFN-α | 6.15 (2.8-12.8) | 5 (1.3-49.35) | 5 (2.4-22.4) | 0.8974 |
| IFN-ɣ | 11.5 (0.4-17.7) | 16.85 (6.4-29.7) | 18.1 (6.5-28.15) | 0.0456 |
| TNF-α | 0.7 (0.4-0.7) | 4.3 (0.7-14)∗ | 2.1 (0.7-13.28)∗ | 0.0003 |
| MCP-1 | 152.8 (115.3-217.7) | 188.1 (143.9-242) | 220.3 (154-255.5)∗ | 0.0318 |
| IL-6 | 1 (0.5-3.7) | 3.5 (0.5-9)∗ | 2.4 (1.1-5.6) | 0.0278 |
| IL-8 | 1.3 (0.6-2.6) | 3.1 (1.5-8.6)∗ | 3.9 (1.1-6.7)∗ | 0.0032 |
| IL-10 | 1.35 (0.6-2.7) | 3.15 (1.3-4.5)∗ | 3.1 (0.6-5.9)∗ | 0.0093 |
| IL-12 | 0.9 (0.7-1.9) | 2.65 (1.2-3.5)∗ | 2.3 (0.8-3.5)∗ | 0.0013 |
| IL-17A | 0.3 (0.3-0.3) | 5.45 (0.35-15.23)∗ | 4.25 (0.3-22.4)∗ | <0.0001 |
| IL-18 | 84.45 (50.25-167) | 121.8 (81.8-212.5) | 145.1 (110.7-199.8)∗ | 0.0124 |
| IL-23 | 2.85 (0.3-4.8) | 8.6 (4.85-14.3)∗ | 8.3 (5.1-16.4)∗ | <0.0001 |
| IL-33 | 3.6 (3.6-18.5) | 63.95 (20.8-155.2)∗ | 54.65 (38.7-121.1)∗ | <0.0001 |
Data is presented as median and interquartile range for nonparametric data and as mean ± s.d. for parametric data. Tests performed with ANOVA/Bonferroni or Kruskal-Wallis/Dunn as described in Methods. Statistical difference vs. NW is represented with ∗. IL: interleukin; TNF: tumor necrosis factor; IFN: interferon; MCP: monocyte chemoattractant protein; MHO: metabolically healthy obesity; MUO: metabolically unhealthy obesity; NW: normal weight.