Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 25;2020:6687185. doi: 10.1155/2020/6687185

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Nan Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Homeostatic regulation and function of mitochondrial ROS (mtROS). (a) Under physical conditions, mtROS homeostasis is maintained by ROS generation (including ROS production at OMM, IMM, and matrix) and ROS scavenging (including ROS elimination at IMM and matrix) in mitochondria. (b) Mitochondrial ROS is implicated in multiple biological processes including mtDNA damage, mitophagy, apoptosis, energy homeostasis, inflammation, cell survival, proteostasis, and lipid peroxidation. OMM: outer mitochondrial membrane; NOX4: nicotinamide adenine dinucleotide phosphate oxidase subunit 4; MAO: monoamine oxidases; Cb5R: cytochrome b5 reductase; IMM: mitochondrial intermembrane space; CI: complex I; BCKD: branched-chain ketoacid dehydrogenase; GPDH: glycerol-3-phosphate dehydrogenase; CYP450: cytochrome P450; KGDHC: α-ketoglutarate dehydrogenase; PDHC: pyruvate dehydrogenase complex; SDH: succinate dehydrogenase; ACO: aconitase; SOD: superoxide dismutase; MSRA: methionine sulphoxide reductase A; CAT: catalase; GSH: glutathione; Grx2/5: glutaredoxin 2 and glutaredoxin 5; Trx2: thioredoxin 2; Prdx3/5: peroxiredoxin 3 and peroxiredoxin 5; GR: glutathione reductase; GPx: glutathione peroxidase; PDHK: pyruvate dehydrogenase kinase; ROS: reactive oxygen species.