Table 1.
Correlation of predicted microRNA in regulating IRBP and retinal disease.
| Predicted miRNA | Reported miRNA | Regulation | Site | Disease or model | References | Others |
|---|---|---|---|---|---|---|
| hsa-miR-152-5p | hsa-miR-152 | Down | Human vitreous | AMD vs. Con | Ménard et al., 2016 | |
| hsa-miR-22-3p | hsa-miR-22 | Down | Human retina | AMD vs. Con | Lukiw et al., 2012 | |
| hsa-miR-146b-3p | Same | Down | Human vitreous | Diabetic vs. Con | Fulzele et al., 2015 | |
| hsa-miR-3121-5p | hsa-miR-3121 | Up | Human serum | dry AMD vs. Con | Szemraj et al., 2015 | |
| hsa-miR-1306-5p | Same | Up | Human plasma | Glaucoma & XFS vs. Con | Hindle et al., 2019 | |
| hsa-miR-3173-5p | hsa-miR-3173 | Up | Human aqueous humor | Glaucoma & XFS vs. Con | Hindle et al., 2019 | |
| hsa-miR-4448 | Same | Up | Human aqueous humor | Glaucoma & XFS vs. Con | Hindle et al., 2019 | |
| hsa-miR-152-5p | hsa-miR-152 | Down | hREC | HG condition vs. Con | Haque et al., 2015 | In vitro |
| hsa-miR-185-3p | Same | Down | Rabbit retina | Newborn vs. Adult | Robert et al., 2010 | Rabbit |
| hsa-miR-18a-3p | Same | Down | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-410-3p | Same | Up | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-4433b-3p | Same | Up | Human aqueous humor | POAG vs. cataract | Liu et al., 2018 | |
| hsa-miR-487a-5p | Same | Up | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-501-3p | Same | Up | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-760 | Same | Up | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-874-3p | Same | Down | Human aqueous humor | POAG vs. Cataract | Liu et al., 2018 | |
| hsa-miR-3149 | Same | Up | Human serum | POAG vs. Con (cataract included) | Liu et al., 2019 | |
| hsa-miR-18a-3p | hsa-miR-18a | Up | Human retina | RB vs. Con | Martin et al., 2013 | |
| hsa-miR-22-3p | hsa-miR-22 | Down | Human retina | RB vs. Con | Martin et al., 2013 | |
| hsa-miR-504-3p | hsa-miR-504 | Down | Human retina | RB vs. Con | Martin et al., 2013 | |
| hsa-miR-874-3p | hsa-miR-874 | Down | Human retina | RB vs. Con | Martin et al., 2013 | |
| hsa-miR-214-3p | Same | Down | Human plasma | ROP vs. Con | Metin et al., 2018 | |
| hsa-miR-223-5p | Same | Up | Human vitreous | severe PVR vs. mild PVR | Toro et al., 2020 | |
| hsa-miR-1909-5p | Same | Up | ARPE-19 cell | TGFβ2 induced EMT vs. Con | Chen et al., 2014 | In vitro |
| hsa-miR-223-5p | Same | Up | ARPE-19 cell | TGFβ2 induced EMT vs. Con | Chen et al., 2014 | In vitro |
| hsa-miR-146b-3p | hsa-miR-146b-5p | Down | Human plasma | wet AMD vs. Con | Ertekin et al., 2014 | |
| hsa-miR-324-3p | Same | Up | Human plasma | wet AMD vs. Con | Ertekin et al., 2014 | Express only in patient group |
| hsa-miR-410-3p | hsa-miR-410 | Down | Human plasma | wet AMD vs. Con | Ertekin et al., 2014 | |
| hsa-miR-574-5p | hsa-miR-574-3p | Down | Human plasma | wet AMD vs. Con | Ertekin et al., 2014 |
hREC, human retinal endothelial cells; XFS, exfoliation syndrome; Con, control; AMD, age-related macular degeneration; HG, high glucose; RB, retinoblastoma; POAG, primary open-angle glaucoma; EMT, epithelial-mesenchymal transition; ROP, retinopathy of Prematurity; PVR, proliferative vitreoretinopathy.