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. 2020 Nov 19;8:588255. doi: 10.3389/fbioe.2020.588255

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Copyright © 2020 Guan, Wang, Guan, Jin, Lin, Ji and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycyrrhetinic acid biosynthetic pathway designed in engineered S. cerevisiae. AACT, acetyl-CoA C-acetyltransferase; HMGS, 3-hydroxy-3- methylglutaryl-CoA synthase; HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; MK, mevalonate kinase; PMK, phosphomevalonate kinase; MDC, mevalonate diphosphate decarboxylase; GPP, geranyl diphosphate; GPPS, geranyl diphosphate synthase; IDI, isopentenyl-pyrophosphate delta isomerase; FPP, farnesyl diphosphate; FPPS, farnesyl diphosphate synthase; SQS, squalene synthase; SQE, squalene epoxidase; β-AS, β-amyrin synthase; CPR, cytochrome P450 reductase; GuGUAT, Glycyrrhiza uralensis UDP-dependent glucuronosyltransferases; MVA, mevalonic acid; MVAP, mevalonate phosphate; MVAPP, mevalonate diphosphate; IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate.