Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Clin Cancer Res. 2020 Aug 17;26(23):6310–6320. doi: 10.1158/1078-0432.CCR-20-0270

Figure 2. Unsupervised analysis of genome-wide methylation of HGSC-precursor lesions of the fallopian tube.

Figure 2.

(A) Methylation heatmap showing the 1000 most variable CpG probes as determined by MethylationEPIC analysis. (B) Corresponding multidimensional analysis showing relative clustering of adjacent-normal epithelia (dashed red line). (C) Sample dendrogram showing that the majority of adjacent-normal epithelia and p53 signature lesion are readily distinguishable from STIC lesions and HGSC tumors. STIC-HGSC pairs are shown in bold red. FTM – Fallopian tube mucosa, FTE – Fallopian Tube Epithelium