Table 2.
High-confidence DHMRs exhibiting HGSC/STIC-specific hypermethylation.
| Genomic Location* | Gene | STIC vs. Adj. norm. FTE AUC |
HGSC VS. Healthy FTM AUC |
HGSC & STIC vs. Healthy FTM & Adj. norm FTE AUC |
|---|---|---|---|---|
| chr5:141208649-141208659 | PCDHB12 | 0.958 | 0.673 | 0.723 |
| chr5:141407937-141407940 | PCDHGB6,PCDHGA1,PCDHGA2,PCDHGA3,PCDHGA4, | 0.875 | 0.793 | 0.813 |
| chr5:141417605-141417623 | PCDHGB7,PCDHGA1,PCDHGA10,PCDHGA2,PCDHGA3 | 0.833 | 0.88 | 0.871 |
| chr19:50667559-50667804 | SHANK1 | 0.826 | 0.745 | 0.761 |
| chr3:187737583-187737946 | BCL6 | 0.826 | 0.807 | 0.81 |
| chr17:60421510-60421683 | C17orf64 | 0.819 | 0.924 | 0.879 |
| chr11:2271280-2271282 | ASCL2 | 0.812 | 0.789 | 0.753 |
| chr11:131910988-131911000 | NTM | 0.806 | 0.855 | 0.804 |
| chr17:37745219-37745526 | HNF1B | 0.778 | 0.633 | 0.737 |
| chr2:153871394-153871412 | GALNT13 | 0.771 | 0.782 | 0.746 |
| chr6:26183280-26183344 | HIST1H2BE | 0.771 | 0.782 | 0.765 |
| chr12:38905914-38906042 | CPNE8 | 0.722 | 0.836 | 0.784 |
| chr12:24903146-24903193 | BCAT1 | 0.694 | 0.676 | 0.699 |
| chr6:26043976-26044177 | HIST1H2BB,HIST1H3C | 0.632 | 0.815 | 0.76 |
| chr17:37743962-37744227 | HNF1B | 0.625 | 0.531 | 0.555 |
| chr2:42792857-42792873 | HAAO | 0.549 | 0.829 | 0.717 |
| chr6:31815145-31815220 | HSPA1A,HSPA1L | 0.507 | 0.716 | 0.651 |
| Mean: | 0.753 | 0.769 | 0.755 | |
| Standard Deviation: | 0.118 | 0.098 | 0.077 | |
| Wilcoxan p-value: | 0.679 | |||
*
Coordinates refer to the human reference genome hg38 release (Genome Reference Consortium GRCh38, Dec 2013).