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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Cancer Discov. 2020 Sep 23;10(12):1968–1987. doi: 10.1158/2159-8290.CD-20-0461

Figure 7. Schematic illustrating G34W-mediated epigenetic remodeling and ECM remodeling by subpopulations of GCT stromal cells.

Figure 7.

(A) Schematic illustrating G34W-mediated epigenetic remodeling of neoplastic GCT cells.

(B) Schematic illustrating G34W-dependent differentiation trajectory in stromal cells and interactions with osteoclasts in the bone TME.