Table I:
Oxidative Stress Protection in Longevity Models
| Longevity Model | Median Survival Age Wild Type (Months) | % Increase Lifespan Compared to Wild Type |
|---|---|---|
| Longevity Models with Known Protection Against Oxidative Stress | ||
| Calorie Restriction | 30 | Up to 50 |
| Snell Dwarf | 18 | 50 |
| Adenylyl Cyclase Type 5 Knockout (AC5 KO) | 25 | 32 |
| Growth Hormone Receptor Knockout (GHR KO) | 27 | 31 |
| p66 SHC-Transforming Protein 1 (p66 shc) Knockout | 26 | 30 |
| Angiotensin II Receptor Type 1 Alpha Knockout (Agtr1 α−/− KO) | 26 | 26 |
| Regulator of G Protein Signaling 14 Knockout (RGS14 KO) | 23 | 26 |
| Insulin-like Growth Factor Type 1 Receptor Hetero (IGF-1R+/− Hetero) | 21 | 24 |
| Klotho Overexpression | 32 | 22 |
| Mitochondrial Targeted Catalase (MCAT) Overexpression | 25 | 19 |
| Ribosomal Protein S6 Kinase β−1 (S6K1) Knockout | 28 | 19 |
| A Longevity Model Not Protected Against Oxidative Stress | ||
| Growth Hormone Receptor/Binding Protein Knockout (GHR/BP KO) | 23 | 47 |
| Longevity Models With Oxidative Stress Protection Controversial | ||
| Ames Dwarf | 21 | 57 |
| Mitochondrial 5-Demethoxyubiquinone Hydroxylase Hetero (Mclk1+/−) | 22 | 31 |
| Insulin Receptor Substrate 1 Knockout (IRS1 KO) | 24 | 18 |
| Longevity Models With Oxidative Stress Not Studied | ||
| Phosphoenolpyruvate Carboxykinase (PEPCK-C) Overexpression | Age unspecified, but the mice still reproduce after age 30 months | |
| Pregnancy-Associated Plasma Protein-A Knockout (PAPPA KO) | 21 | 26 |