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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Ageing Res Rev. 2020 Oct 19;64:101194. doi: 10.1016/j.arr.2020.101194

Table II-c:

Protective Features of Longevity Models With Oxidative Stress Protection Controversial

MODEL IMPROVED EXERCISE OBESITY PROTECTION DIABETES PROTECTION CV STRESS PROTECTION CANCER PROTECTION PROTECTION OBSERVED IN OLD AGE DECREASED β-ADRENERGIC SIGNALING
Ames Dwarf ? + + + +/− ?
Mitochondrial 5-Demethoxyubiquinone Hydroxylase Hetero (Mclk1+/−) ? ? ? ? + ? ?
Insulin Receptor Substrate 1 KO ? + +/− +/− +