Table 2.
Conditional logistic regression analysis to identify metabolites significantly associated with breast cancer
| Model 1* | Model 2# | |||||
|---|---|---|---|---|---|---|
| Metabolites | Pathways | Sub-pathways | OR (95% CI) | P value | OR (95% CI) | P value |
| 3-hydroxyoctanoate | Lipid | Fatty Acid, Monohydroxy | 1.55 (1.13, 3.32) | 0.016 | 1.51 (1.10, 3.47) | 0.022 |
| 3-hydroxybutyrate (BHBA) | Lipid | Ketone Bodies | 1.47 (1.11, 3.72) | 0.020 | 1.42 (1.01, 3.72) | 0.049 |
| stearate (18:0) | Lipid | Long Chain Fatty Acid | 1.22 (0.83, 4.01) | 0.235 | 1.26 (0.79, 4.24) | 0.332 |
| 3-hydroxydecanoate | Lipid | Fatty Acid, Monohydroxy | 1.29 (0.87, 4.09) | 0.203 | 1.35 (0.86, 4.27) | 0.194 |
| linoleate (18:2n6) | Lipid | Polyunsaturated Fatty Acid (n3 and n6) | 1.38 (1.06, 3.93) | 0.043 | 1.39 (1.07, 4.04) | 0.041 |
| 10-nonadecenoate (19:ln9) | Lipid | Long Chain Fatty Acid | 1.33 (1.05, 4.04) | 0.044 | 1.30 (0.96, 4.14) | 0.060 |
| dihomo-linoleate | Lipid | Polyunsaturated Fatty Acid (n3 and n6) | 1.20 (0.73, 3.99) | 0.589 | 1.15 (0.63, 4.02) | 0.764 |
| 3-methylxanthine | Xenobiotics | Xanthine Metabolism Hemoglobin and Porphyrin | 0.80 (0.32, 2.80) | 0.504 | 0.85 (0.33, 3.51) | 0.619 |
| bilirubin | Cofactors/Vitamins | Metabolism | 0.50 (0.47, 0.90) | 0.034 | 0.54 (0.42, 0.95) | 0.041 |
| 1-palmitoyl-GPA (16:0) glucuronate | Lipid | Lysolipid | 0.89 (0.45, 3.16) | 0.744 | 0.90 (0.40, 3.81) | 0.778 |
| Carbohydrate | Aminosugar Metabolism | 0.90 (0.32, 4.53) | 0.796 | 0.95 (0.33, 4.72) | 0.904 | |
| 1-(1-enyl-stearoyl)-2-dihomo-linolenoyl-GPE | Lipid | Plasmalogen Urea cycle; Arginine and Proline | 0.62 (0.33, 1.25) | 0.146 | 0.70 (0.35, 1.30) | 0.166 |
| urea | Amino Acid | Metabolism | 1.11 (0.59, 4.08) | 0.646 | 1.12 (0.58, 4.16) | 0.639 |
| sphingomyelin | Lipid | Sphingolipid Metabolism | 0.90 (0.41, 4.28) | 0.826 | 0.92 (0.34, 4.51) | 0.854 |
*.
Adjusted by parity, education, birth place, language acculturation, and BMI category.
#.
Adjusted by parity, education, birth place, language acculturation, and BMI category, smoking status, alcohol status, sitting time, and physical activity.