Table 3.

Stratified analysis to assess the association between candidate metabolites and breast cancer

Variable	3-hydroxyoctanoate*	linoleate (18:2n6)*	bilirubin*
	OR (95%CI)	OR (95%CI)	OR (95%CI)
Age at enrollment, years
<51 years	1.53 (1.03, 4.46)	1.41 (0.89, 5.98)	0.57 (0.35, 1.06)
≥51 years	1.47 (1.05, 4.37)	1.37 (0.82, 5.71)	0.50 (0.31, 1.01)
Parity
0–2 children	1.49 (1.06, 4.40)	1.44 (0.85, 5.83)	0.51 (0.36, 1.04)
>2 children	1.54 (1.05, 4.33)	1.35 (0.80, 5.64)	0.58 (0.39, 1.07)
Education level
<High school	1.54 (1.07, 3.92)	1.40 (0.86, 5.77)	0.55 (0.35, 1.05)
≥High school	1.44 (0.90, 4.67)	1.37 (0.81, 5.58)	0.53 (0.34, 1.03)
Place of birth
Mexico	1.49 (1.04, 4.04)	1.37 (1.00, 5.36)	0.51 (0.32, 0.99)
United States	1.61 (0.72, 5.73)	1.47 (0.65, 6.34)	0.63 (0.26, 1.63)
Language acculturation
Low	1.50 (1.03, 4.12)	1.36 (1.01, 5.29)	0.52 (0.34, 0.98)
High	1.55 (0.82, 5.69)	1.48 (0.62, 6.55)	0.64 (0.24, 1.71)
BMI category
Non-obese	1.46 (1.04, 4.12)	1.32 (0.76, 5.48)	0.53 (0.33, 0.99)
Obese	1.58 (1.06, 4.30)	1.48 (1.01, 5.14)	0.54 (0.34, 0.98)
Smoking status
Never	1.54 (1.07, 3.99)	1.38 (1.02, 4.56)	0.54 (0.35, 0.98)
Ever	1.40 (0.76, 5.68)	1.45 (0.65, 6.39)	0.57 (0.21, 1.89)
Alcohol drinking
Never	1.53 (1.06, 4.01)	1.40 (1.04, 4.69)	0.55 (0.34, 0.97)
Ever	1.46 (0.86, 5.09)	1.34 (0.60, 6.12)	0.51 (0.22, 1.84)
Physical activity
Low	1.52 (1.07, 3.86)	1.41 (1.05, 4.71)	0.53 (0.35, 0.97)
Medium or high	1.39 (0.70, 5.38)	1.32 (0.59, 6.03)	0.59 (0.24, 1.91)
Sitting hours per day
0–4	1.47 (1.03, 4.39)	1.38 (1.02, 4.49)	0.52 (0.29, 1.06)
>4	1.55 (1.06, 4.48)	1.41 (1.03, 4.51)	0.56 (0.33, 1.09)
Time between blood collection and cancer diagnosis
≤5 years	1.65 (1.07, 4.38)	1.57 (1.06, 4.78)	0.51 (0.30, 0.96)
>5 years	1.33 (1.01, 5.06)	1.30 (0.85, 5.43)	0.55 (0.25, 0.99)

^*.Adjusted by parity, education, birth place, language acculturation, and BMI category, smoking status, alcohol status, sitting time, and physical activity, as appropriate.