Table 1.
Demographics of total cohort with SDHx pathogenic variants.
| HCI | U of M | Penn | Total | Percent | |
|---|---|---|---|---|---|
| Cohort | |||||
| Total Subjects (n) | 100 | 95 | 68 | 263 | .. |
| Families (n) | 25 | 48 | 51 | 124 | .. |
| Families with >1 member (n) | 17 | 38 | 34 | 89 | .. |
| Sex | |||||
| Females (n) | 48 | 54 | 44 | 146 | 56% |
| Males (n) | 52 | 41 | 24 | 117 | 44% |
| Age at end of study | |||||
| Mean age (y) | 38 | 43 | 47 | 42 | .. |
| Median age (y) | 39 | 42 | 47 | 41 | .. |
| Age min (y) | 8 | 6 | 20 | 8 | .. |
| Age max (y) | 77 | 90 | 76 | 90 | .. |
| Adults and Children | |||||
| Age <18 (n) | 17 | 9 | 0 | 26 | 10% |
| Age ≥18 (n) | 83 | 86 | 68 | 237 | 90% |
| Germline Genetics | |||||
| SDHA (n) | 1 | 4 | 4 | 9 | 3% |
| SDHB (n) | 72 | 62 | 54 | 188 | 71% |
| SDHC (n) | 12 | 13 | 3 | 28 | 11% |
| SDHD (n) | 15 | 13 | 7 | 35 | 13% |
| SDHAF2 (n) | 0 | 3 | 0 | 3 | 1% |
HCI: Huntsman Cancer Institute; U of M: University of Michigan; Penn: University of Pennsylvania