Table 3.

Clinical findings in different levels of dry eye disease (DED) clinical severity based on Dry Eye Workshop (DEWS) classification.

	DEWS Clinical Severity in DED Group
	Level 1(n = 97)	Level 2(n = 106)	Level 3(n = 65)	Level 4(n = 26)	p (GLM)
Conjunctival Injection	0.48 ± 0.09	0.42 ± 0.10	0.52 ± 0.11	1.03 ± 0.06*†‡	0.007
Lissamine Conjunctival Staining	0.96 ± 0.18	1.19 ± 0.18	1.58 ± 0.16*	1.36 ± 0.10*†	0.021
Fluorescein Corneal Staining	0.83 ± 0.11	1.29 ± 0.10*	1.85 ± 0.14*†	2.04 ± 0.07*†	< 0.001
Tear BreakUp Time (TBUT) (seconds)	6.90 ± 0.27	4.68 ± 0.20*	2.99 ± 0.25*†	2.40 ± 0.16*†	< 0.001
Schirmer’s Score(mm)	14.89 ± 0.48	11.13 ± 0.55*	6.05 ± 0.57*†	1.24 ± 0.39*†‡	< 0.001
OSDI	38.77 ± 5.39	50.43 ± 5.18	39.01 ± 5.20	49.61 ± 2.93	0.293

Data presented as mean ± standard deviation.

^*p < 0.05 compared to level 1;

^†p < 0.05 compared to level 2;

^‡p < 0.05 compared to level 3 assessed by GLM.