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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Ageing Res Rev. 2020 Sep 28;64:101189. doi: 10.1016/j.arr.2020.101189

Figure 3. Scheme of cerebromicrovascular mechanisms contributing to the pathogenesis of age-related vascular cognitive impairment.

Figure 3.

Nutritional lifestyle interventions, such as CR, have proved to be efficacious in preventing and, at least partially, reversing the downstream consequence of vascular aging. In humans, adherence to CR regimen remains a challenge and a translational barrier. Alternative nutritional strategies tailored to the needs of older adults must be developed to reap health benefits similar to that offered by CR while limiting the risk of undesired adverse effects.