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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Cancer Discov. 2020 Jul 29;10(12):1950–1967. doi: 10.1158/2159-8290.CD-19-1274

Figure 7. Genetic and Physical Interaction Mapping Reveal New Facets of RAS Pathway Biology.

Figure 7

Schematic of RAS pathway features identified in this study. Among them are new, paralog-specific RAS/effector GI and PPIs, heterogeneity in GIs between MAPK pathway components, new roles in membrane dynamics for the RAS effectors RIN and RADIL, a striking intersection between RAS and RAP signaling, and synthetic lethal GIs between RALA and RALB and between RAP1GDS1 and RHOA that are contingent on KRAS activity.