Table 9.
Average level of 25(OH)D (ng/ml) in subjects in winter, depending on the genotypes of cytochrome gene polymorphisms.
| Allele | n | Level 25(OH)D in winter, M ± m, Me (Q1-Q3) | p | |
|---|---|---|---|---|
| CYP2C9*3 (1075A>C; I359L) | AA CA |
106 14 |
35.3 ± 20.6, 31.7 (23.5–44.6) 31.7 ± 21.3, 25.0 (15.0–35.9) |
0.241 |
| CYP3A4*3 (c.1334T>C; M445T) | TT CT |
84 0 |
34.9 ± 20.6, 31.5 (23.2–41.8) - |
– |
| CYP2C9*2 (c.430C>T; R144C) | CC CT |
98 22 |
34.8 ± 21.6, 31.7 (23.1–39.2) 35.6 ± 15.9, 28.6 (23.5–45.0) |
0.618 |
| CYP2D6*4 (c.1846G>A) | AA AG GG |
7 31 79 |
25.6 ± 11.2, 26.7 (13.3–31.3) 43.7 ± 32.4, 32.7 (23.6–47.5) 32.1 ± 13.4, 31.7 (22.3–39.7) |
0.119 |
| CYP3A4 *1B (c.-392C>T) | TT CT |
113 6 |
35.1 ± 20.5, 31.7 (23.3–40.8) 25.0 ± 14.4, 23.1 (11.6–36.0) |
– |
p is the significance level of differences, and Kruskal–Wallis test was applied.