REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Caveolin-1	GeneTex	#GTX100205; RRID:AB_1240559
Anti-Caveolin-1	Abcam	#AB2910; RRID:AB_303405
α-tubulin	Sigma	#T9026; RRID:AB_477593
Anti-Pax6	Abcam	#AB5790; RRID:AB_305110
Anti-mouse HRP-conjugate	Promega	#W4021; RRID:AB_430834
Anti-rabbit HRP-conjugate	Promega	#W4011; RRID:AB_430833
Donkey anti-rabbit Alexa568 secondary	Invitrogen	#A10042; RRID:AB_2534017
Donkey anti-mouse Alexa488 secondary	Invitrogen	#A-21202; RRID:AB_141607
Chemicals, Peptides and Recombinant Proteins
Alt-R® S.p. Cas9 Nuclease V3	Integrated DNA technologies	#1081059
Alt-R® Cas9 Electroporation Enhancer	Integrated DNA technologies	#1075915
Dulbecco’s Modified Eagle medium	Lonza	#12-604F
RPMI-1640 medium with L-glutamine	Lonza	#BE12-702F
Neurobasal medium	ThermoFisher Scientific	#12348017
Penicillin-Streptomycin	Sigma	#P4333
Fibronectin	Merck	#FC010
10x Trypsin	Sigma	#59427C
Foetal bovine serum	ThermoFisher Scientific	#10270106
L-glutamine (200mM)	ThermoFisher Scientific	#25030081
Agarose	Melford	#MB1200
Ethidium bromide solution	Sigma	#E1510
VeriFi mix red	PCRBio	#PB10.42-01
Tri reagent	Sigma	#93289-100ML
M-MLV reverse transcriptase	ThermoFisher Scientific	#28025-013
5x First Strand buffer	ThermoFisher Scientific	#18057-018
0.1M Dithiothreitol	ThermoFisher Scientific	#707265ML
dNTP Mix	ThermoFisher Scientific	#10534823
SYBR Green Brilliant III master mix	Agilent	#600882
Random hexamer primer	ThermoFisher Scientific	#SO142
Pre-stained protein ladder	Abcam	#116028
Bradford reagent	Bio-Rad	#5000001
Laemmli buffer	Bio-Rad	#1610747
b-mercaptoethanol	Sigma	#M6250
EDTA	Sigma	#E5134
HEPES	Sigma	#H3375
SigmaFAST Protease Inhibitor Cocktail tablets	Sigma	#S8820
PMSF protease inhibitor	ThermoFisher Scientific	#36978
Clarity Western ECL blotting substrate	Bio-Rad	#1705060S
TracrRNA	Integrated DNA technologies	#1072533
TE Buffer, RNase-free pH 8	ThermoFisher Scientific	#AM9849
Dulbecco’s Phosphate Buffered Saline	Sigma	#D8537-500ML
Triton X-100	Sigma-Aldrich	#T8787
Normal horse serum	Vector	#S-2000-20
Hoechst 33342	ThermoFisher Scientific	#62249
All-trans retinoic acid	Sigma	#R2625
BDNF	PeproTech	#450-02
N-2 supplement	ThermoFisher Scientific	#17502048
Cholera Toxin Subunit B (recombinant) Alexa555 Conjugate	Invitrogen	#C22843
Critical Commercial Assays
Pierce BCA Assay Protein Assay Kit	ThermoFisher Scientific	#23225
GenElute Mammalian Genomic DNA Miniprep Kit	Sigma	#G1N350
Direct-zol RNA Miniprep Kit	Zymo Research	#R2050
Neon Transfection System 10 μL Kit	ThermoFisher Scientific	#MPK1096
Alt-R CRISPR-Cas9 Control Kit, Human, 2 nmol	Integrated DNA technologies	#1072554
Experimental Models: Cell Lines
SH-SY5Y	ATCC	Cat.#CRL-2266
Patient and control LCL lines	MNDA (UK) DNA Bank	N/A
Oligonucleotides
See Supplementary Table S5		N/A
Software and Algorithms
SKAT	https://cran.r-project.org/web/packages/SKAT/index.html	N/A
R	https://cran.r-project.org/mirrors.html	N/A
Galaxy	https://usegalaxy.org/	N/A
snpStats	https://www.bioconductor.org/packages/release/bioc/html/snpStats.html	N/A
VariantAnnotation	https://www.bioconductor.org/packages/release/bioc/html/VariantAnnotation.html	N/A
Plink	http://zzz.bwh.harvard.edu/plink/download.shtml	N/A
PRISM 7	GraphPad	N/A
ICE CRISPR analysis tool	https://ice.synthego.com/#/	N/A
CRISPOR guide RNA design tool	http://crispor.tefor.net/	N/A
CFX Maestro	Bio-Rad	N/A
Harmony High-Content Imaging and Analysis Software	PerkinElmer	N/A
FIJI (FIJI Is Just ImageJ)	NIH	N/A