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. 2020 Dec 2;11(12):1028. doi: 10.1038/s41419-020-03200-7

Fig. 7. Autophagy was involved in the regulation of SKIL/TAZ on STING signaling pathway.

Fig. 7

a Western blot result showed that overexpression of either SKIL or TAZ decreased expression of STING in CALU-3 and NCI-H520, which was reversed by inhibition on autophagy using autophagy inhibitor (bafilomycin). b, c In CALU-3 and NCI-H520, treatment of cGAMP, a STING pathway agonist, resulted in increased p-TBK1 and p-IRF3. SKIL or TAZ overexpression decreased levels of p-TBK1 and p-IRF3, which was canceled by bafilomycin. d, e In CALU-3 and NCI-H520, SKIL or TAZ overexpression significantly inhibited cGAMP-induced expression of IFN-β and CXCL10, while treatment of bafilomycin canceled the inhibition. *P < 0.05, **P < 0.01, ***P < 0.001. Experiments were performed in triplicate.