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. 2020 Dec 2;11(12):1031. doi: 10.1038/s41419-020-03237-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — (a, b) circXPO1 expression in 76 pairs of LUAD tumor tissues and adjacent lung tissues measured by qRT-PCR. (c) The circXPO1 expression level in patients with tumors ≥3 cm and <3 cm (non-paired student test was performed). (d) The circXPO1 expression level in patients with different TNM stages (non-paired student test was performed). (e) Kaplan–Meier analysis of circXPO1 in 76 LUAD patients (HR = 1.878, 95% CI: 1.002–3.52, P = 0.0491 with the Kaplan–Meier method). (f, g) Kaplan-Meier analysis of circXPO1 in another cohort of 61 LUAD patient (HR = 2.28, 95% CI: 1.21–6.66, P = 0.016 with the Kaplan–Meier method). CircXPO1 expression was classified by mean fold change (tumor vs. normal) in d and e.