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. 2020 Dec 2;11:6161. doi: 10.1038/s41467-020-20001-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Relative 5hmC-modification levels on tissue-specific 5hmC-enriched genes in each tissue type. Rows are distinct 5hmC-modified genes. Higher z score indicates enrichment; lower z score indicate depletion of 5hmC signal. Lower panel, numbers of tissue-specific 5hmC-enriched genes for each tissue type. Dashed line represents 100. b Functional enrichment for tissue-specific 5hmC-enriched genes. Only tissues with over 100 tissue-specific 5hmC-enriched genes are shown. Top 5 enriched functional terms are ranked by enrichment significance. c Heatmap showing fold enrichment of tissue-specific 5hmC-modified genes with tissue-specific expressed genes from accompanying RNA-Seq data. d t-SNE clustering of genomic 5hmC distributions on exons for all donor tissue samples. Colored symbols indicate the organ/tissue associated with each 5hmC profile.

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