Table 1.
MIC50 values for garvicin KS and micrococcin P1 determined in liquid culture for the indicated strains.
| Antimicrobial (mg/ml) | Strain | |||||
|---|---|---|---|---|---|---|
| ATCC 10832 | Newman | USA 300 | ATCC 29213 | ATCC 33591 | S.a. 3255 | |
| Individual component | ||||||
| Garvicin KS | 2.5 × 10−2 | 2.5 × 10−2 | 2.5 × 10−2 | 2.5 × 10−2 | 5 × 10−2 | 2.5 × 10−2 |
| Micrococcin P1 | 6.3 × 10−4 | 3.13 × 10−4 | 6.3 × 10−4 | 2.5 × 10−3 | >1 × 10−2 | 1 × 10−2 |
| Combination | ||||||
| Garvicin KS | 6.3 × 10−3 | 3.13 × 10−3 | 1.56 × 10−3 | 1.3 × 10−2 | 1.3 × 10−2 | 1.3 × 10−2 |
| Micrococcin P1 | 6.3 × 10−4 | 3.13 × 10−4 | 1.56 × 10−4 | 1.3 × 10−3 | 1.3 × 10−3 | 1.3 × 10−3 |
| FICa | 1.25 | 1.13 | 0.31 | 1.04 | 0.39 | 0.65 |
aSynergy achieved with fractional inhibition concentration (FIC) ≤ 0.5.